English
norskBlar i forfatter "Cauzzo, Jennifer"
Viser treff 1-6 av 6
-
Characterization of Liposomes Using Quantitative Phase Microscopy (QPM)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-21)The rapid development of nanomedicine and drug delivery systems calls for new and effective characterization techniques that can accurately characterize both the properties and the behavior of nanosystems. Standard methods such as dynamic light scattering (DLS) and fluorescent-based assays present challenges in terms of system’s instability, machine sensitivity, and loss of tracking ability, among ... -
Dyes in Disguise: characterization of fluorescently labeled liposomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)The rather limited success of translation from basic research to clinical application has been highlighted as a major issue in the nanomedicine field. To identify the factors influencing the applicability of nanosystems as drug carriers and potential nanomedicine, we focused on following their fate through fluorescence-based assays, namely flow cytometry and imaging. These methods are often used to ... -
Following the fate of dye-containing liposomes in vitro
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)The rather limited success of translation from basic research to clinical application has been highlighted as a major issue in the nanomedicine field. To identify the factors influencing the applicability of nanosystems as drug carriers and potential nanomedicine, we focused on following their fate through fluorescence-based assays, namely flow cytometry and imaging. These methods are often used to ... -
Label-free imaging on waveguide platform with enhanced resolution and contrast
(Conference object; Konferansebidrag, 2021)Chip-based Evanescent Light Scattering (cELS) utilizes the multiple modes of a high-index contrast optical waveguide for near-field illumination of unlabeled samples, thereby repositioning the highest spatial frequencies of the sample into the far-field. The multiple modes scattering off the sample with different phase differences is engineered to have random spatial distributions within the integration ... -
Microscopy Meets Nanomedicine: The Challenge of Liposomes. Selecting, Understanding, and Adapting Imaging Techniques to Localize and Characterize Nanocarriers
(Doctoral thesis; Doktorgradsavhandling, 2022-06-10)Nanocarriers have brought several medical advances through better diagnostics and improved drug therapy. Yet, many promising preclinical findings were never translated into clinical success, consequently slowing drug development, and increasing its financial burden. By reliably predicting the nanoparticle fate at in vitro stages, the disappointment of suboptimal in vivo outcome could be avoided. To ... -
Multi-moded high-index contrast optical waveguide for super-contrast high-resolution label-free microscopy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-20)The article elucidates the physical mechanism behind the generation of superior-contrast and highresolution label-free images using an optical waveguide. Imaging is realized by employing a high index contrast multi-moded waveguide as a partially coherent light source. The modes provide near-field illumination of unlabeled samples, thereby repositioning the higher spatial frequencies of the ...
